Hemolíticas. Keywords: Autoimmune hemolytic anemia, cold agglutinin disease, autoantibodies, treatment. Palabras clave: Anemia hemolitica autoinmune. Request PDF on ResearchGate | Protocolo diagnóstico de las anemias hemolíticas | The hemolytic anemias diagnosis remains a clinical challenge. Once a. Download Citation on ResearchGate | On Nov 1, , M. J. García Rodríguez and others published Protocolo diagnóstico de las anemias hemolíticas.

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Nouv Rev Fr Hematol. Pulmonary hypertension in sickle cell disease.

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The splenomegaly seen in this case could be explained because the spleen is the major site of RBC destruction, and thus splenectomy may slow the premature elimination of PK-deficient RBCs. Intravenous injection of sonicated blood induces pulmonary microthromboembolism in rabbits with ligation of the splenic artery. As there was also a decline in platelet and leukocyte counts, a hematopoietic failure for other reasons than PK-deficiency may have been present.

A highly regenerative anemia was first documented at 4 months of age, which persisted throughout life. Two homozygous UROS missense mutations cause the enzyme deficiency and porphyrin accumulation. Hypoxaemia in sickle cell disease: While PK-deficient cats and humans may also develop bilirubin calculi and gall bladder blockade, this has not been reported in PK-deficient dogs.

J Vet Intern Med 9, Therefore, properly designed clinical trials evaluating rituximab as salvage- and first-line-therapy for the treatment of AIHA and cold agglutinin disease are clearly warranted. Indeed, dogs can become sensitized to other RBC antigens than one can test for and thus be incompatible to even the “universal donor” Callan et alBlais et alKessler et al Identification of a 6 base pair insertion in West Highland White Terriers with erythrocyte pyruvate kinase deficiency.


Kohn B, C Fumi. Radiographs from this WHWT terrier described here revealed only a mildly decreased bone radiopacity of the pelvic bones, probably due to the young age of the animal Chapman and GigerHarvey et alVan Geffen et al Usually the dogs that live longer develop severe liver disease with hemosiderosis.

Causes of death in hemolkticas cell disease: Enhanced thrombin generation in children with sickle cell disease.

Fax 1 E-mail: J Feline Med Surg 10, Hemoltiicas test for pyruvate kinase deficiency of Basenjis. In this case, the patient could be negative for Dal or another antigen. The high erythrocytic content of 2,3-DPG facilitates the easy release of oxygen from hemoglobin by the lower hemoglobin-oxygen affinity, which in turn improves oxygen delivery and enhances tissue oxygenation, thereby ameliorating the clinical signs of the severe anemia. In order to prevent the further spread of this and other hereditary diseases, it is essential to recognize not only the affected animals, but also the carriers that can transmit the mutant allele to their offspring.

N Engl J Med.

Anemia Hemolítica Autoinmune

Mortality in sickle cell disease. J Assoc Acad Minor Phys. A massive reticulocytosis was confirmed on anfmias New Methylene Blue-stained blood smear. Breed-specific hereditary diseases and genetic screening.

Indeed, many PK-deficient dogs are not diagnosed until one to several years of age, as the animals can often adapt hemolitifas to the severe chronic anemia. Regenerative anemias caused by blood loss or hemolysis. These studies have and will bring benefits for humans and for animals.


Hemolytic anemia caused by hereditary hemolihicas kinase deficiency in a West Highland White Terrier dog. Bilirubin cholelithiasis and haemosiderosis in an anaemic pyruvate kinase-deficient Somali cat.

REDACCIÓN MÉDICA: El Clínico investigará la mutación que causa las anemias hemolíticas

While in the past PK-deficiency was diagnosed by erythrocytic enzymatic activity test, assessment of oxygenhemoglobin dissociation curve, and level of intermediates of the glycolytic pathway, such as 2,3-DPG, a definitive diagnosis in this case was established simply with the PCR mutation-specific test.

For yet unexplained reasons, all PK-deficient dogs develop a progressive myelofibrosis and then osteosclerosis, as seen in this case, though PK-deficient cats and humans do not experience osteoclerosis.

The effect of anticoagulant therapy in primary and anorectic drug-induced pulmonary hypertension. J Vet Intern Med 21, Inherited metabolic disease in companion animals: Thus, splenectomy may only be considered as a last resort in dogs that are persistently severely anemic or have frequently severe crises and are transfusion dependent. Blood transfusions from compatible donors are sometimes needed when the anemia becomes most severe and the PK-deficient animal shows major clinical signs.