Palmoplantar keratodermas (PPKs) are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the palms and soles. What are the other Names for this Condition? (Also known as/Synonyms). Acquired Palmoplantar Keratoderma; Acquired PPK. Paraneoplastic palmoplantar keratoderma (PPK) is an acquired dermatosis that presents with hyperkeratosis of the palms and soles in association with visceral.

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Palmoplantar keratoderma

This chapter kfratoderma a practical overview of keratoderma, keratderma is set out as below: They can be very effective for some patients, but cannot be used in fertile women due to their teratogenicity. Occasionally keratoderma can affect other parts of the body It can be difficult to differentiate between the different types of keratoderma, however, the management principles are similarand as such the key diagnostic elements are to exclude the rare malignant or other systemic causes.

The cutaneous features usually pre-date the diagnosis of the cancer. Keratoderma of the soles and acanthosis nigricans of the hands in a patient with bladder carcinoma. All are rare Epidermolytic keratoderma Vorner’s keratoderma and non-epidermolytic keratoderma Thost-Unna keratoderma are two of the best described forms Both are autosomal dominant Clinically the features can be indistinguishable with the development, usually in infancy, of diffuse, yellow, thickened skin affecting the palms and soles.

Aetiology Clinical findings Images Investigations Management. Notice and credit must be given to the PCDS or other named contributor. The vast majority are associated with adenocarcinoma of the stomach, but other malignancies sometimes found include other GI tract tumours, lung, uterus, ovaries, and urinary tract Tripe palms – the appearance differs to that of keratoderma with thickened velvety palms that have the appearance of tripe.


In order to avoid the possibility of overlooking an underlying etiology and to eliminate excessive kfratoderma, we present an algorithm for assessing patients presenting with acquired PPK. Axial CT images showing multiple polypoidal enhancing mass lesions with surface calcifications, in the urinary bladder. All named individuals and organisations maintain copyright for the relevant images. The first step should include a comprehensive history and a physical examination, including a complete skin examination.

Any findings suggestive of underlying conditions should be aggressively evaluated and treated. The palms of the hands may be affected with discrete, centrally placed lesions.

Palmoplantar keratoderma | Primary Care Dermatology Society | UK

Palmoplantar keratoderma is a term used to define a marked thickening of the skin on the palms and soles, either as a focal entity, or diffuse. If no pertinent findings are identified after a history and a physical examination, laboratory and radiology studies should be undertaken in a systematic, logical fashion. In cases keratoderna tripe palms occur without AN, xcquired cancers are usually responsible. It is associated with squamous cell carcinoma of the upper aerodigestive tract oral cavity, pharynx, larynx, oesophagus.

There is usually a well-defined erythematous border The two conditions vary in their histological features Several others types have been described. A painful paronychia develops with no evidence of bacterial or fungal infection. Any image downloaded must only be used for teaching purposes and not for commercial use. Website author — Dr Tim Cunliffe read more. Please click on images to enlarge or download. Keratoderma can be inherited, acquired, and rarely, paraneoplastic ie secondary to an internal malignancy.

To facilitate such evaluations, this review categorizes the acquired PPKs as: Keratoderma may be hereditarywith symptoms presenting in early childhood, or acquired when it presents in later life. Palmoplantar keratodermas PPKs are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the palms and soles.


Some people with focal palmoplantar keratoderma also have abnormalities of the fingernails and toenails There are several inherited typeswhich are all rare. Three stages have been described: In terms of treatment, the most successful results occur when the underlying etiology is diagnosed and treated.

Acquired keratoderma | DermNet NZ

It is often associated with acanthosis nigricans AN. Clinical classification Keratoderma can keratodefma defined by its clinical appearance, although there is often overlap: Web Design – Mode Ten Designs. If findings are consistent with a hereditary keratoderma, then a genetics consultation should be considered.

Etretinate and acitretin have also shown some success as alternative treatments in recalcitrant cases. Rarely keratoderma can be associated with malignancy. If no such etiology is evident, then conservative treatment options include topical keratolytics urea, salicylic acid, lactic acidrepeated physical debridement, topical retinoids, topical psoralen plus UVA, and topical corticosteroids.

acqiired This website is non-profit and holds the images for educational purposes only. It usually affects the sole of the feet around the margins of the heel and under the metatarsal heads.

Please follow this link if you have any high-quality images that you can contribute to the website. Given the numerous possible underlying causes for acquired PPKs, evaluation of patients presenting with acquired PPK can be a perplexing task.